A young thoracic surgeon becomes indebted to the South Chicago mafia and is forced to moonlight as a mob doctor, while also working full time at Chicago's most prominent hospital.

Erica Shepherd is a brilliant former CIA operative, now known as the most notorious traitor in American history serving life in a Supermax prison. Against every fiber of his being but with nowhere else to turn, FBI Agent Will Keaton enlists Shepherd to help track down a fiercely dangerous and elusive criminal she knows all too well. While Shepherd and Keaton have different motivations for bringing the enemy to justice, they both know that to catch a spy… they must think like one.